Casasicilia Carlo V Hotel is situated in the heart of Palermo and features Wi-Fi throughout the property. This guest house offers private car parking nearby.

Such city attractions as San Giuseppe dei Teatini, which is around a 10-minute walk from the accommodation, and Capuchin Catacombs, which is a 10-minute drive away, are well worth a visit. The 2-star hotel is also a stroll from such natural sights as Orto Botanico. There is Foro Italico Lawn a 19-minute stroll away, and Via Paolo Balsamo bus station only a 10-minute walk from this property. For those travelling from afar, Falcone-Borsellino airport is 30 minutes' drive away.

Welcoming guests to a balcony and a dressing room, the rooms are furnished with a writing table. For more comfort dressing gowns and shower caps along with a bidet, a separate toilet, and a shower are provided. They offer views of the city.

The Casasicilia Carlo V features a buffet breakfast daily. Guests can dine at the bakery Pasticceria Porta Sant'agata located approximately 5 minutes' walk away.